Tutor Qualification:Master's Advisor

Department:Department of Microbiology

E-mail：[email protected]

Research direction:Molecular mechanism of RNA virus-host interaction

Personal profile

In June 2009, he received a doctor's degree in Microbiology from Sun Yat-sen University. Since July 2009, he has been engaged in the molecular mechanism of interaction between RNA virus (ZIKV/DENV/HIV-1) and host in Sun Yat-sen Medical College, Sun Yat-sen University. He has made a series of important research achievements in the field of molecular mechanism of host factors, especially lipid metabolism related factors, regulating viral replication. He is also the corresponding author (co-corresponding author) and the first author of the Journal of Virology, Journal of Biological Chemistry, Virology, Retrovirology, Frontiers in Science He has published more than 10 SCI papers in Microbiology, Frontiers in Cellular and Infection Microbiology, and BMC Medicine. In recent years, he has hosted 2 projects of the National Natural Science Foundation, 2 projects of the Natural Science Foundation of Guangdong Province, 1 project of the Provincial Science and Technology Program of Guangdong Province, 1 sub-project of the Innovation Team of Guangdong Province, 1 special fund for doctoral programs of universities and 1 Postdoctoral Science Fund of China, and was selected as the top young talents of the Guangdong Special Support Plan in 2016.

Academic achievement

Academic works and textbooks

  1. Wang Y, Huo ZT, Lin QS, Lin YX, Chen CC, Huang YX, Huang CB, Zhang JS, He JF, Liu C*, Zhang P*. Positive Feedback Loop of Long Noncoding RNA OASL-IT1 and Innate Immune Response Restricts the Replication of Zika Virus in Epithelial A549 Cells. Journal of Innate Immunity. 2021. 13(3):179-193.
  2. Huang YX#, Lin QS#, Huo ZT, Chen CC, Zhou SL, Ma XC, Gao HX, Lin YX, Li XB, He JF, Zhang P*, Liu C*. Inositol-Requiring Enzyme 1 alpha Promotes Zika Virus Infection through Regulation of Stearoyl Coenzyme A Desaturase 1-Mediated Lipid Metabolism. Journal of Virology. 2020. 94(23):e01229-20.
  3. Ma XC, Luo X, Zhou SL, Huang YX, Chen CC, Huang CB, Shen L, Zhang P, and Liu C*. Hydroxycarboxylic Acid Receptor 2 Is a Zika Virus Restriction Factor That Can Be Induced by Zika Virus Infection Through the IRE1-XBP1 Pathway. Frontiers in Cellular and Infection Microbiology. 2020. 9: 480.
  4. Lin QS#, Zhou SL#, Huang YX, Huo ZT, Chen CC, Luo X, He JF, Liu C*,  Zhang P*. ANKS4B Restricts Replication of Zika Virus by Downregulating the Autophagy. Frontiers in Microbiology. 2020. 11: 1745.
  5. Zhou SL, Yang C, Zhao FF, Huang YX, Lin YX, Huang CB, Ma XC, Du JJ, Wang Y, Long G, He JF, Liu C*, and Zhang P*. Double-stranded RNA deaminase ADAR1 promotes the Zika virus replication by inhibiting the activation of protein kinase PKR. J Biol Chem. 2019. 294(48) : 18168-18180.
  6. Gao HX#, Lin YX#, He JF, Zhou SL, Liang MJ, Huang CB, Li XB, Liu C*, and Zhang P*. Role of heparan sulfate in the Zika virus entry, replication, and cell death. Virology. 2019. 529: 91-100.
  7. Chen CC, Ma XC, Hu QF, Li XH, Huang F, Zhang JS, Pan T, Xia JY, Liu C*, and Zhang H. Moloney leukemia virus 10 (MOV10) inhibits the degradation of APOBEC3G through interference with the Vif-mediated ubiquitin–proteasome pathway. Retrovirology. 2017. 14: 56.
  8. Liu C, Ma XC, Liu BF, Chen CC, Zhang H*. HIV-1 functional cure: will the dream come true? BMC Medicine. 2015. 13: 284.
  9. Huang F#, Zhang JS#, Zhang YJ, Geng GN, Liang JR, Li YN, Chen JL, Liu C*, and Zhang H. RNA helicase MOV10 functions as a co-factor of HIV-1 Rev to facilitate Rev/RRE-dependent nuclear export of viral mRNAs. Virology. 2015. 486:15-26.
  10. Yin Y, Zhang SY, Luo HH, Zhang X, Geng GN, Li J, Guo XM, Cai WP, Li LH, Liu C*, and Zhang H*. Interleukin 7 up-regulates CD95 protein on CD4+ T cells by affecting mRNA alternative splicing: priming for a synergistic effect on HIV-1 reservoir maintenance. J Biol Chem. 2015. 290(1):35-45.
  11. Zhou XX#, Luo J#, Mills L#, Wu SX, Pan T, Geng GN, Zhang J, Luo HH, Liu C*, and Zhang H*. DDX5 facilitates HIV-1 replication as a cellular co-factor of Rev. PLoS ONE. 2013. 8(5): e65040.
  12. Liu C*, Zhang X, Huang F, Yang B, Li J, Liu BF, Luo HH, Zhang P, and Zhang H*. APOBEC3G Inhibits microRNA-mediated repression of translation by interfering with the interaction between argonaute-2 and MOV10. J Biol Chem. 2012. 287: 29373-29383.